Development of Organosilicon Peroxides as Practical Alkyl Radical Precursors and Their Applications to Transition Metal Catalysis

This account highlights the development of efficient methods for generation alkyl radicals from organosilicon peroxides and their applications in selective alkylation reactions. Compared with commonly used organic peroxides, a more diverse range can be prepared as bench-stable radical precursors, use combination transition metal catalysts allows under mild conditions. Consequently, these have opened up new way formation various carbon–carbon carbon–heteroatom bonds, affording highly functionalized carbon skeletons chemoselective or asymmetric manners. Efficient structurally been developed. In presence suitable catalyst, generated reaction conditions, which successfully involved bonds to construct